Implaclean®, the toothpaste for people with dental implants!


  • safe for dental implant
  • constructions
  • unique and patented (radical-free safe active oxygen) technology
  • lactoferrin
  • low concentration of fluoride
  • neutral pH value
  • non-abrasive
  • reduces oral malodour
  • scientifically supported

Implaclean® has been specifically developed for people with dental implants and is essential for maintaining proper hygiene.

Oral diseases

Many oral diseases are associated with the presence of harmful bacteria. These bacteria live in a poor oxygen environment or an environment without oxygen. The characteristic of these anaerobe micro-organisms is that oxygen forms a threat to them.

The treatment of these oral diseases is mainly focused on the reduction of the pathogenic micro-organisms. In most cases this is reached by a better oral hygiene and professional teeth cleaning (deep cleaning).


Known anaerobe bacteriaRelated to
Actinobacillus actinomy
Parodontitis / peri-implantitis
Treponema denticolagingivitis / peri-implantitis
Porphyromonas gingivalisparodontitis / peri-implantitis
Prevotella intermediagingivitis / peri-implantitis
Bacteroides forsythusParodontitis
Streptococcus mutansCaries

Active oxygen technology

Implaclean® with active oxygen is a new generation toothpaste based on the patented Ardox-X® technology, which releases – during multiple hours – non-radical active oxygen in a controlled manner. Once Implaclean® is applied, the released anionic oxygen particles break through the cell wall of the bacteria which then disintegrate.

The active oxygen particIe is highly volatile and so small that it penetrates into the deeper layers of the tissue which allows it to be effective in the whole treatment region. Active oxygen is a natural component and ph neutral. It does not contain any alcohol, chemical disinfectants or peroxides.

The success of Implaclean® is due to the Ardox-X® technology, a molecular complex that donates radical-free (safe) active oxygen (O-). The use of safe oxygen for medical treatment has been used for over 50 years with hyperbaric oxygen treatment (HBOT) as the most well known treatment.

Implaclean® helps the elimination of the harmful bacteria. It works for a long period and helps the reduction of the growth of new bacteria. Possible pockets of teeth and implants are kept clean and free of damaging bacteria and gum infections have no chance. The active oxygen assures that plaque formation is prevented, teeth stay white and no deviations in color between the natural teeth and implant constructions occur over time. Implaclean® also contains lactoferrin which is a protein that is present in saliva, tears, mucous and breast milk. In combination with active oxygen it has an antibacterial, antiparasitary and antiviral effect. Dangerous bacteria get no chance of survival in this way and the teeth and implants stay in optimal condition.

Implaclean® also contains a neutral pH value and a low level of fluoride. Research confirms that titanium can be damaged by a high concentration of fluoride. These days almost all toothpastes have high levels of fluoride (>1200 ppm F-). Implaclean® however contains a low level of fluoride (+/- 200 ppm F-) and is non-abrasive.

Research Implaclean®

In a recent double-blind study at the University of Milan, Implaclean has been shown to reduce and prevent the formation of the harmful biofilm. An impressive result!

The biofilm is a mucus layer consisting of bacteria, sugars and proteins that makes the bacteria less sensitive to medicines. In addition, the pathogens can multiply in this to your heart’s content.

Abstract research

Aim of the in vivo study is to assess if a toothpaste containing an oxygen releasing compound (AX) is able to reduce the biofilm formation on implants with rough surface compared to a control toothpaste, without affecting the microstructure of the tested surface.

Methods: In this double blind, cross-over, controlled clinical trial, a total of fourteen healthy volunteers were recruited. For each subject, two mandibular splints (test and control) were created with one implant fixed on the right lingual side of the mandibular arch. The splint was continuously worn for 5 days and the daily hygiene was performed wearing the splint and using the test (AX) or control toothpaste. Implants were analyzed at scanning-electron-microscopy and at laser profilometer for the assessment of biofilm adhesion (% of areas free from biofilm-FA) and surface changes (morphology and roughness).

Results: FA resulted significantly higher in test than in control implants. No differences were found between groups in term of biofilm organization, surface microstructure and roughness.

Discussion: Daily use of toothpaste containing AX seems to reduce the amount of biofilm adherent to the rough implant surface without corrosion or degradation of the titanium surface.


  1. Elena Canciani, Riccardo Sirello, Claudia Dellavia, Giacomo Begnoni, Dolaji Henin, Gaia Pellegrini. Implant Surfaces Exposed to the Oral Cavity and Treated with Toothpaste Containing Oxygen Releasing Compound: A Morphological Controlled Clinical Trial
  2. Berendsen JLM, el Allati I, Sylva LH, Blijdorp PA, Van Damme PhA, Meijer GJ. Ardox-X® adjunctive topical active oxygen application in periodontitis and peri-implantitis – a non published pilot study
  3. Boere G Academic Centre for Dentistry Amsterdam (ACTA), Department of Dental Materials Science, The Netherlands, Influence of fluoride on titanium in an acidic environment measured by polarization resistance technique. J Appl Biomater. 1995 Winter;6(4):283-8
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  6. Ide K, Hattori M, Yoshinari M, Kawada E, Oda Y. , Department of Dental Materials Science, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, Japan 261-8502. The influence of albumin on corrosion resistance of titanium in fluoride solution. Dent Mater J. 2003 Sep;22(3):359-70.
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